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KMID : 1134820070360121511
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Journal of the Korean Society of Food Science and Nutrition
2007 Volume.36 No. 12 p.1511 ~ p.1516
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Inhibitory Effects of Eucommia ulmoides Extract on Angiotensin Converting Enzyme
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Shon Mi-Yae
Nam Sang-Hae
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Abstract
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To assess a potential possibility of Eucommia ulmoides (EU) as a functional food, anti-hypertensive materials of EU were isolated by silica gel column, thin layer and reverse phase column chromatographies, and then ACE (angiotensin-converting emzyme) inhibitory activities of different parts (leaf, bark, and stem) were investigated. The isolated compound, 8A, was pinoresinol-4,4’-di-O-β-D-glucoside (below PDG) originating from Eucommial Cortex and its purity was 95.64%. Of all the samples tested, PDG in raw bark and roasted bark was the highest level at 135.13 ㎎% and 163.67 ㎎%, respectively. In ACE inhibitory activity at 10 ㎎/mL of EU extracts, roasted leaf, raw bark, and roasted bark were 77.56%, 75.73%, and 75.73%, respectively. ACE activities at 1 ㎎/mL were shown to be 91.87% for PDG, 97.06% for Enalapril®, and 90.32% for Captopril®.
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KEYWORD
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Eucommia ulmoides, pinoresinol-4, 4’-di-O-β-D-glucoside (PDG), ACE inhibitory activity
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